Miranda Wilmot
Published research has observed a seesaw mechanism between plant regeneration and wounding defense. What remains unknown is if this seesaw mechanism occurs between regeneration and systemic pathogen defense. We investigated the relationship between systemic acquired resistance (SAR) and regeneration by testing the effect flg22 (a flagellin peptide that elicits a systemic pathogen response), has on a series of published mutants with a perturbed Glutamate-Like Receptor Pathway. This will allow us to better define the relationship between these two phenomena and determine how plants can be modified in the future to ensure better growth and quality.
Xiao Wang
Histone variant H2A.Z.2 plays important role in facilitating proper chromosome alignment and segregation and thus ensures genome integrity in human cells. However, whether its role is regulated by mitotic kinases remains unknown. I discovered that the phenotype caused by H2A.Z.2 overexpression is affected by kinase inhibitor treatment. Through in vitro kinase assay, I also discovered that H2A.Z.2 is very likely to be phosphorylated by Monopolar Spindle 1 (Mps1) at Serine 99 site. I further found that this phosphorylation may not directly alter the function of Chromosomal Passenger Complex (CPC). These experiments led to further investigation on H2A.Z.2’s regulation by kinases.
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